(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

Base Information

Chemical Name:(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid
CAS No.:197575-03-4
Molecular Formula:C₂₉H₃₁NO₈
Molecular Weight:521.567
Hs Code.:

Synonyms:(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

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Chemical Property of (R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

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Technology Process of (R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

There total 5 articles about (R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 598-78-7,7474-05-7,29617-66-1,62138-52-7
L-2-chloropropionic acid

: 197574-99-5
2-naphthylmethyl 2-acetamido-2-deoxy-4,6-O-benzylidene-β-D-glucopyranoside

: 197575-03-4
(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

Guidance literature:: With sodium hydride; Multistep reaction; 1) dioxane, 95 deg C, 1 h, 2) dioxane, 65 deg C, 3 h;
DOI:10.1007/BF02273926

Reference yield:

: 1592-38-7
2-Naphthalenemethanol

: 197575-03-4
(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / HgI₂, 3 Angstroem molecular sieves / CH₂Cl₂

2: 96 percent / CH₃ONa / methanol

3: 94 percent / H₂SO₄ / dioxane; methanol / 0.08 h / 90 - 95 °C

4: 1) NaH / 1) dioxane, 95 deg C, 1 h, 2) dioxane, 65 deg C, 3 h

With 3 A molecular sieve; sulfuric acid; sodium methylate; sodium hydride; mercury(II) iodide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1007/BF02273926

Reference yield:

: 190181-66-9
(2-naphthyl)methyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside

: 197575-03-4
(R)-2-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-6-(naphthalen-2-ylmethoxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / CH₃ONa / methanol

2: 94 percent / H₂SO₄ / dioxane; methanol / 0.08 h / 90 - 95 °C

3: 1) NaH / 1) dioxane, 95 deg C, 1 h, 2) dioxane, 65 deg C, 3 h

With sulfuric acid; sodium methylate; sodium hydride; In 1,4-dioxane; methanol;
DOI:10.1007/BF02273926