2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

Base Information

Chemical Name:2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile
CAS No.:468104-15-6
Molecular Formula:C₁₉H₁₇NO
Molecular Weight:275.35
Hs Code.:
DSSTox Substance ID:DTXSID401147908

Synonyms:DTXSID401147908;2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile;468104-15-6

Suppliers and Price of 2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:275.131014166
Heavy Atom Count:21
Complexity:426

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(CC(C2=CC#N)CC3=CC=CC=C3)C=C1

Technology Process of 2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

There total 1 articles about 2-[2,3-Dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16307-12-3
2,3-dihydro-6-methoxy-2-phenylmethyl-1H-inden-1-one

: 75-05-8,26809-02-9
acetonitrile

: 468104-15-6
[2,3-dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

Guidance literature:: acetonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃;

2,3-dihydro-6-methoxy-2-phenylmethyl-1H-inden-1-one; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm020114g

Reference yield:

: 468104-15-6
[2,3-dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

: 468104-20-3
2-[2,3-dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]ethanamine

Guidance literature:: With ammonia; hydrogen; cobalt; In ethanol; at 40 ℃; under 3000.24 Torr;
DOI:10.1021/jm020114g

Reference yield:

: 468104-15-6
[2,3-dihydro-6-methoxy-2-(phenylmethyl)-1H-inden-1-ylidene]acetonitrile

: 2,2,2-Trifluoro-N-[2-(2-benzyl-5-methoxy-1H-inden-3-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂; NH₃ / Raney-cobalt / ethanol / 40 °C / 3000.24 Torr

2: 24 percent / HCl / ethanol / 13 h / 70 °C

3: Et₃N / tetrahydrofuran / 0 °C

With hydrogenchloride; ammonia; hydrogen; triethylamine; cobalt; In tetrahydrofuran; ethanol;
DOI:10.1021/jm020114g