16307-12-3Relevant academic research and scientific papers
Photocatalytic acylarylation of unactivated alkenes with diaryliodonium salts toward indanones and related compounds
Chen, Yongtao,Shu, Chenyun,Luo, Fang,Xiao, Xiaohui,Zhu, Gangguo
supporting information, p. 5373 - 5376 (2018/06/01)
A novel photocatalytic acylarylation of unactivated alkenes using diaryliodonium salts as the arylation reagent is described. The reaction produces a variety of 2-benzyl indanones, 3,4-dihydronaphthalen-1(2H)-ones, and 2,3-dihydroquinolin-4(1H)-ones in pr
Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation
Walker, James A.,Vickerman, Kevin L.,Humke, Jenna N.,Stanley, Levi M.
, p. 10228 - 10231 (2017/08/10)
We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.
Benzocycloalkene compounds, their production and use
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, (2008/06/13)
A compound of the formula STR1 wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a hydrocarbon group; ring A represents a substituted benzene ring; X represents a C2-4 alkylene group etc.; and Y represents a bond or a lower alkylene group, or salts thereof is useful as prophylactic or therapeutic agents of diseases related with melatonin activity.
Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
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, (2008/06/13)
Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.
Studies in Antifertility Agents: Part XXVI - Synthesis of 1--2-benzyl-5- and 6-methoxyindanes
Malik, Mangel S.,Rastogi, Shri Nivas
, p. 382 - 385 (2007/10/02)
2-Benzyl-5- and 6-methoxyindan-1-ones (5,6), prepared by catalytic hydrogenation of 2-benzylideneindan-1-ones (3,4) on KBH4 reduction give 2-benzylindan-1-ols (7,8).Friedel-Crafts acetylation of 7 and 8 with phenol results in a mixture of 1-(o- and p-hydr
