(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

Base Information

Chemical Name:(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane
CAS No.:125113-24-8
Molecular Formula:C₃₄H₄₇NO₃SSi
Molecular Weight:577.904
Hs Code.:

Synonyms:(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

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Technology Process of (rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

There total 9 articles about (rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109-72-8,29786-93-4
n-butyllithium

: 125113-20-4
cis-4-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonylcyclohex-3-ene

: 125113-24-8
(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

Guidance literature:: In tetrahydrofuran; at -78 - -10 ℃;

Reference yield:

: 107657-92-1
trans-4-hydroxy-3-phenylsulfenylcyclohex-1-ene

: 125113-24-8
(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / MCPBA / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 17 h

2: 76 percent / DBU / tetrahydrofuran / 0.5 h

3: 86 percent / AgNO₃ / tetrahydrofuran / 0.02 h

4: 1.70 g / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

5: CH₂Cl₂ / 0.01 h / -20 °C

6: 80 percent / tetrahydrofuran / -78 - -10 °C

With silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1165952-91-9
cyclohexa-1,3-diene

: 125113-24-8
(rel-1S,2R,3S,4R)-1-(t-butyldiphenylsilyloxy)-2-dimethylamino-3-phenylsulfonyl-4-n-butylcyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) MeCO₃H, 2.) Et₃N / 1.) toluene, room temperature, 3 h, 2.) room temperature, 2 h

2: 91 percent / MCPBA / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 17 h

3: 76 percent / DBU / tetrahydrofuran / 0.5 h

4: 86 percent / AgNO₃ / tetrahydrofuran / 0.02 h

5: 1.70 g / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

6: CH₂Cl₂ / 0.01 h / -20 °C

7: 80 percent / tetrahydrofuran / -78 - -10 °C

With peracetic acid; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;