2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine

Base Information

• Chemical Name: 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine
• CAS No.: 177978-37-9
• Molecular Formula: C₄₀H₅₀N₆O₇Si
• Molecular Weight: 755.951

Synonyms:2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine

Chemical Property:

Purity/Quality:

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine

There total 8 articles about 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-dimethylaminomethylene[1'-2H]guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N2-dimethylaminomethylene[1'-2H]guanosine (177978-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: imidazole / pyridine

With pyridine; 1H-imidazole; In pyridine;

DOI:10.1135/cccc19960389

Reference yield:

N2-acetyl-O6-(diphenylcarbamoyl)guanine (112233-74-6) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N2-dimethylaminomethylene[1'-2H]guanosine (177978-37-9)

Guidance literature:

Multi-step reaction with 5 steps

1: N,O-bis(trimethylsilyl)acetamide, CF₃SO₃Si(CH₃)3 / CH₂Cl₂; toluene

2: NH₄OH, MeOH / 24 h

4: pyridine

5: imidazole / pyridine

With pyridine; 1H-imidazole; methanol; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In pyridine; dichloromethane; toluene;

DOI:10.1135/cccc19960389

Reference yield:

<1'-2H>guanosine (151453-44-0) → 2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N2-dimethylaminomethylene[1'-2H]guanosine (177978-37-9)

Guidance literature:

Multi-step reaction with 3 steps

2: pyridine

3: imidazole / pyridine

With pyridine; 1H-imidazole; In pyridine;

DOI:10.1135/cccc19960389

upstream raw materials:

tert-butyldimethylsilyl chloride

C₃₄H₃₅⁽²⁾HN₆O₇

4,4'-dimethoxytrityl chloride

N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

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