Technology Process of Dah(Boc)-Ala-Gly-Pro-Ile-NHBn
There total 6 articles about Dah(Boc)-Ala-Gly-Pro-Ile-NHBn which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
In
dichloromethane;
for 16h;
DOI:10.1021/jm9903139
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: H2 / Pd-C / methanol / 1 h / 20 °C / 3000.3 Torr
1.2: 80 percent / DIEA; HOBT; DCC / DCM / 20 °C
2.1: TFA / CH2Cl2 / 0.5 h / 0 °C
3.1: 97 percent / DCC; HOBt; DIPEA / CH2Cl2 / 16 h
With
hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane;
1.1: Catalytic hydrogenation / 1.2: Substitution / 2.1: acidolysis / 3.1: Acylation;
DOI:10.1021/jm9903139
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: DCM; TFA
1.2: 92 percent / DCC; HOBT; DIPEA/DCM
2.1: H2 / Pd-C / methanol / 1 h / 20 °C / 3000.3 Torr
2.2: 80 percent / DIEA; HOBT; DCC / DCM / 20 °C
3.1: TFA / CH2Cl2 / 0.5 h / 0 °C
4.1: 97 percent / DCC; HOBt; DIPEA / CH2Cl2 / 16 h
With
hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane;
1.1: Catalytic hydrogenation / 1.2: Substitution / 2.1: Catalytic hydrogenation / 2.2: Substitution / 3.1: acidolysis / 4.1: Acylation;
DOI:10.1021/jm9903139
