29776-78-1Relevant articles and documents
Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor
Boukanoun, Meriem K.,Hou, Xin,Nikolajev, Ljiljana,Ratni, Sara,Olson, David,Claing, Audrey,Laporte, Stéphane A.,Chemtob, Sylvain,Lubell, William D.
, p. 7750 - 7761 (2015)
On pursuing molecules that delay labour, so-called tocolytics, the prostaglandin F2α receptor (FP) was targeted, because of its role in the stimulation of uterine contractions leading to birth and preterm birth. Previously, both the indolizidin
5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS
-
Paragraph 0234; 0235; 0236; 0282; 0284, (2018/08/20)
Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
Molecular design and structure - Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
Das, Jagabandhu,Kimball,Hall, Steven E.,Han, Wen-Ching,Iwanowicz, Edwin,Lin, James,Moquin, Robert V.,Reid, Joyce A.,Sack, John S.,Malley, Mary F.,Chang, Chiehying Y.,Chong, Saeho,Wang-Iverson, David B.,Roberts, Daniel G.M.,Seiler, Steven M.,Schumacher, William A.,Ogletree, Martin L.
, p. 45 - 49 (2007/10/03)
A series of structurally novel small molecule inhibitors of human α-thrombin was prepared to elucidate their structure-activity relationships (SARs), selectivity and activity in vivo. BMS-189664 (3) is identified as a potent, selective, and orally active reversible inhibitor of human α-thrombin which is efficacious in vivo in a mouse lethality model, and at inhibiting both arterial and venous thrombosis in cynomolgus monkey models.
