(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
CAS No.:94607-94-0
Molecular Formula:C₂₉H₃₇NO₇
Molecular Weight:511.615
Hs Code.:

Synonyms:(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Chemical Property of (2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Technology Process of (2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 1 articles about (2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79477-05-7
(2R,3S,6S)-6-(2,2-Diethoxy-ethyl)-3-hydroxy-2-vinyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 94607-94-0
(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:

Reference yield: 88.0%

: 107-30-2
chloromethyl methyl ether

: 94607-94-0
(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: (2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-methoxymethoxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 8h; Heating;

Reference yield:

: 94607-94-0
(2R,3S,6S)-3-Benzoyloxy-6-(2,2-diethoxy-ethyl)-2-((S)-1-hydroxy-propyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 94608-06-7
[(2R,6R)-6-((R)-1-Methoxymethoxy-propyl)-1-(3-{(toluene-4-sulfonyl)-[4-(2,2,2-trifluoro-acetylamino)-butyl]-amino}-propyl)-1,2,5,6-tetrahydro-pyridin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 8 h / Heating

2: 100 percent / H₂O, K₂CO₃ / methanol / 2 h / Ambient temperature

3: 1.) 1,1'-thiocarbonyldiimidazole, 2.) Bu₃SnH, AIBN / 1.)ClCH₂CH₂Cl, r.t., 22 h, 2.) benzene, reflux, 10 h

4: Na / NH₃; tetrahydrofuran / 0.08 h / -70 °C

5: K₂CO₃ / toluene; benzene; H₂O / 1.)0 degC, 10 min., 2.) 10 degC, 1 h

6: 86 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

7: 97 percent / K₂CO₃ / dimethylformamide / 22 h / Ambient temperature

8: 80percent NH₂NH₂ / ethanol / 22 h / Ambient temperature

9: Et₃N / CH₂Cl₂ / 0.25 h / -70 °C

10: p-TsOH*H₂O, Me₂CO / 1.) ) degC, 5 min., r.t. 1.5 h

11: Jones reagent, Me₂CO / 0.25 h / 0 °C

12: diethyl ether; methanol / 0.08 h / 0 °C

With lithium aluminium tetrahydride; jones reagent; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-Thiocarbonyldiimidazole; acetone; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ammonia; water; N,N-dimethyl-formamide; toluene; benzene;