(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

Base Information

Chemical Name:(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide
CAS No.:1408237-89-7
Molecular Formula:C₂₆H₃₄N₄O₃
Molecular Weight:450.581
Hs Code.:

Synonyms:(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

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Chemical Property of (S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

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Technology Process of (S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

There total 10 articles about (S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: C₂₅H₃₃N₃O₃

: 1408237-88-6
C₂₆H₃₄N₄O₃

: 1408237-89-7
(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

Guidance literature:: In methanol; at 20 ℃; for 24h; stereoselective reaction;
DOI:10.1016/j.tetasy.2012.07.009

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: C₂₅H₃₃N₃O₃

: 1408237-88-6
C₂₆H₃₄N₄O₃

: 1408237-89-7
(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

: 1408237-87-5
C₃₅H₄₁N₅O₃

Guidance literature:: In dichloromethane; at 0 ℃; for 24h; stereoselective reaction;
DOI:10.1016/j.tetasy.2012.07.009

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1408237-89-7
(S)-N-benzyl-5-[(tert-butoxycarbonyl)-amino]-2-[((S)-1-cyano-2-phenylethyl)amino]-pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 1 h / -20 °C

2.1: dichloromethane / 0 °C

3.1: sodium hydroxide / water; 1,4-dioxane / 0.5 h / 20 °C

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / acetonitrile / 2 h / 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; acetonitrile; 2.1: |Strecker Aminoacid Synthesis;
DOI:10.1016/j.tetasy.2012.07.009