dimethyl 3,5-dihydroxy-4-iodophthalate

Base Information

• Chemical Name: dimethyl 3,5-dihydroxy-4-iodophthalate
• CAS No.: 1417179-23-7
• Molecular Formula: C₁₀H₉IO₆
• Molecular Weight: 352.082
• Mol file: 1417179-23-7.mol

Synonyms:dimethyl 3,5-dihydroxy-4-iodophthalate

Chemical Property of dimethyl 3,5-dihydroxy-4-iodophthalate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl 3,5-dihydroxy-4-iodophthalate

There total 1 articles about dimethyl 3,5-dihydroxy-4-iodophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3,5-Dihydroxy-phthalic acid dimethyl ester (67609-51-2) → dimethyl 3,5-dihydroxy-4-iodophthalate (1417179-23-7)

Guidance literature:

With iodine; periodic acid; In ethanol; water; at 20 ℃; for 6h;

DOI:10.1021/ja3108577

Reference yield: 70.0%

dimethyl 3,5-dihydroxy-4-iodophthalate (1417179-23-7) + 2-methyl-2-hepten-5-in-4-one (103576-51-8) → C18H19IO7 (1417179-25-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 20 ℃; for 80h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja3108577

Reference yield:

dimethyl 3,5-dihydroxy-4-iodophthalate (1417179-23-7) → C30H41IO8Si

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 80 h / 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 2: |Mitsunobu Displacement;

DOI:10.1021/ja3108577

upstream raw materials:

3,5-Dihydroxy-phthalic acid dimethyl ester

Downstream raw materials:

C₁₈H₁₉IO₇