67609-51-2Relevant academic research and scientific papers
A Negishi cross-coupling reaction enables the total synthesis of (+)-stachyflin
Haut, Franz-Lucas,Speck, Klaus,Wildermuth, Raphael,M?ller, Kristof,Mayer, Peter,Magauer, Thomas
, p. 3348 - 3357 (2018)
We present a full account on the development of the total synthesis of the antiviral meroterpenoid (+)-stachyflin. The decalin subunit is rapidly accessed by an exo-selective Diels–Alder reaction, whereas the isonindolinone was synthesized via a highly efficient and practical de novo route starting from dimedone. A challenging sp2–sp3 Negishi cross-coupling reaction enabled construction of the crucial C15–C16 bond that connects the arene with the decalin subunit. For the final installation of the cis-decalin framework, a Lewis acid-catalyzed cyclization was applied.
Total synthesis of (±)-bisabosqual A
Am Ende, Christopher W.,Zhou, Zhou,Parker, Kathlyn A.
supporting information, p. 582 - 585 (2013/03/13)
The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was completed in 14 steps (longest linear sequence) from commercially available starting materials. The doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the
The Regiochemistry of A-Ring-labelled Averufin Incorporation into Aflatoxin B1
Townsend, Craig A.,Davis, Steven G.
, p. 1420 - 1422 (2007/10/02)
A-Ring -labelled averufin has been synthesized and found to be incorporated intact into aflatoxin B1, where the labelling pattern in the fused cyclopentenone unequivocally establishes the origin of the carbon backbone as consistent with cur
