methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

Base Information

Chemical Name:methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate
CAS No.:110707-79-4
Molecular Formula:C₂₅H₃₁N₃O₅
Molecular Weight:453.538
Hs Code.:

methyl 4-<2-<5-<N-(cyclopentylmethyl)carbamoyl>-2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

Synonyms:methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

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Chemical Property of methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

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Technology Process of methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

There total 6 articles about methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 110707-78-3
methyl 4-<2-<5--2-(N-formyl-N-methylamino)phenyl>-2-oxoethyl>-3-methoxybenzoate

: 110707-79-4
methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

Guidance literature:: With pyridine; hydroxylamine hydrochloride; at 120 ℃; for 1.5h;
DOI:10.1021/jm00091a010

Reference yield:

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 110707-79-4
methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h

2: 1.) Ag₂O / 1.) dioxane, reflux, 1 h, 2.) dioxane, reflux, 3.5 h

3: 1.) NaH / 1.) DMF, from 0 deg C to 25 deg C, 35 min, 2.) DMF, 25 deg C, 1 h

4: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) CH₂Cl₂, MeOH, from -78 deg C to RT

5: 66 percent / hydroxylamine hydrochloride, pyridine / 1.5 h / 120 °C

With pyridine; dmap; dimethylsulfide; hydroxylamine hydrochloride; sodium hydride; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; silver(l) oxide; In dichloromethane;
DOI:10.1021/jm00091a010

Reference yield:

: 6053-81-2
cyclopentylmethylamine

: 110707-79-4
methyl 4-<2-<5--2-(N-methylamino)phenyl>-2-(hydroxyimino)ethyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / 4-(dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h

2: 1.) Ag₂O / 1.) dioxane, reflux, 1 h, 2.) dioxane, reflux, 3.5 h

3: 1.) NaH / 1.) DMF, from 0 deg C to 25 deg C, 35 min, 2.) DMF, 25 deg C, 1 h

4: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 15 min, 2.) CH₂Cl₂, MeOH, from -78 deg C to RT

5: 66 percent / hydroxylamine hydrochloride, pyridine / 1.5 h / 120 °C

With pyridine; dmap; dimethylsulfide; hydroxylamine hydrochloride; sodium hydride; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; silver(l) oxide; In dichloromethane;
DOI:10.1021/jm00091a010