{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

Base Information

Chemical Name:{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid
CAS No.:1344996-03-7
Molecular Formula:C₂₈H₃₂F₃N₃O₃S
Molecular Weight:547.642
Hs Code.:

Synonyms:{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

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Chemical Property of {1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

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Technology Process of {1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

There total 14 articles about {1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344998-58-8
C₂₉H₃₄F₃N₃O₃S

: 1344996-03-7
{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

Guidance literature:: C₂₉H₃₄F₃N₃O₃S; With water; sodium hydroxide; In isopropyl alcohol; at 90 ℃; for 4h;

In water; pH=3 - 4;

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 1344996-03-7
{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -70 - -65 °C

2.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C

2.2: 2 h / -10 - 20 °C

2.3: 0.17 h / 0 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

6.1: sodium tetrahydroborate; methanol / 0 - 20 °C

7.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

9.1: sodium hydroxide; water / isopropyl alcohol / 4 h / 90 °C

9.2: pH 3 - 4

With hydrogenchloride; methanol; sodium tetrahydroborate; potassium phosphate; n-butyllithium; carbon tetrabromide; water; isopropylmagnesium bromide; potassium acetate; potassium carbonate; diisopropylamine; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 5.1: Suzuki Coupling;

Reference yield:

: 41053-30-9
1,3-dibromo-2-ethyl-benzene

: 1344996-03-7
{1-[(2-ethyl-3-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}phenyl)methyl]-4-piperidinyl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; isopropylmagnesium bromide / hexane; tetrahydrofuran / 1.17 h / 0 °C

1.2: 2 h / -10 - 20 °C

1.3: 0.17 h / 0 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

5.1: sodium tetrahydroborate; methanol / 0 - 20 °C

6.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

8.1: sodium hydroxide; water / isopropyl alcohol / 4 h / 90 °C

8.2: pH 3 - 4

With hydrogenchloride; methanol; sodium tetrahydroborate; potassium phosphate; n-butyllithium; carbon tetrabromide; water; isopropylmagnesium bromide; potassium acetate; potassium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 4.1: Suzuki Coupling;