[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt

Base Information

• Chemical Name: [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt
• CAS No.: 1187364-41-5
• Molecular Formula: C₁₀H₁₅NO₂*C₃₅H₃₆ClNO₃S
• Molecular Weight: 767.429
• Mol file: 1187364-41-5.mol

Synonyms:[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt

Chemical Property of [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt

There total 2 articles about [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol (807638-71-7) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt (1187364-41-5)

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium methylate; In N,N-dimethyl-formamide; at -5 - 0 ℃;

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol; In N,N-dimethyl-formamide; at -5 - 0 ℃; Inert atmosphere;

2-(3,4-dimethoxyphenyl)-ethylamine;

Reference yield:

1-((mercaptomethyl)cyclopropyl)acetic acid homoveratrylamine salt (1228272-68-1) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol (807638-71-7) → [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt (1187364-41-5)

Guidance literature:

1-((mercaptomethyl)cyclopropyl)acetic acid homoveratrylamine salt; With sodium methylate; In N,N-dimethyl-formamide; at -5 - 0 ℃;

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol; In N,N-dimethyl-formamide; at -5 - 0 ℃; Inert atmosphere;

2-(3,4-dimethoxyphenyl)-ethylamine; Product distribution / selectivity;

Reference yield: 75.0%

[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt (1187364-41-5) → Montelukast sodium (151767-02-1)

Guidance literature:

[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt; With acetic acid; In dichloromethane; water; at 0 - 5 ℃;

With sodium hydroxide; In methanol; at 25 - 35 ℃; Product distribution / selectivity;

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

1-(sulfanylmethyl)cyclopropaneacetic acid

1-((mercaptomethyl)cyclopropyl)acetic acid homoveratrylamine salt

Downstream raw materials:

Montelukast sodium

Refernces