2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol

Base Information

Chemical Name:2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol
CAS No.:807638-71-7
Molecular Formula:C₃₀H₃₀ClNO₄S
Molecular Weight:536.091
Hs Code.:
Mol file:807638-71-7.mol

Synonyms:2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

Suppliers and Price of 2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(methanesulfonyl)oxy]propyl]phenyl]-2-propanol
100mg
$ 1540.00

TRC
2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(methanesulfonyl)oxy]propyl]phenyl]-2-propanol
10mg
$ 195.00

Total 8 raw suppliers

Chemical Property of 2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol

Chemical Property:

Boiling Point:718.6±60.0 °C(Predicted)
PKA:14.46±0.29(Predicted)
Density:1.293±0.06 g/cm3(Predicted)
Solubility.:DCM

Purity/Quality:

≥95% ^*data from raw suppliers

2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(methanesulfonyl)oxy]propyl]phenyl]-2-propanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(methanesulfonyl)oxy]propyl]phenyl]-2-propanol is an intermediate in the synthesis of Montelukast (M568000), a selective leukotriene D4-receptor antagonist used as an antiasthmatic agent.

Technology Process of 2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol

There total 4 articles about 2-[2-[(3S)-3-[3-[(E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[(Methanesulfonyl)oxy]propyl]phenyl]-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.21%

: 124-63-0
methanesulfonyl chloride

: 287930-77-2
(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol

: 807638-71-7
2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

Guidance literature:: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol; With N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile; at 25 - 35 ℃; for 0.25h;

methanesulfonyl chloride; In toluene; acetonitrile; at -30 - -25 ℃; for 5.25h;

Reference yield: 70.94%

: 287930-77-2
(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol

: 7143-01-3
Methanesulfonic anhydride

: 807638-71-7
2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -25 - -20 ℃; for 2.63333h; Product distribution / selectivity;

Reference yield:

: 149968-11-6
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate

: 807638-71-7
2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: (-)-diisopinocamphenylborane chloride / dichloromethane / -5 - 0 °C

2.1: cerium(III) chloride / tetrahydrofuran / 0 - 5 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 0 - 5 °C

3.2: 5 h / -25 °C

With cerium(III) chloride; N-ethyl-N,N-diisopropylamine; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; dichloromethane; acetonitrile; 2.1: Grignard reaction;