(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

Base Information

Chemical Name:(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol
CAS No.:1286204-54-3
Molecular Formula:C₂₆H₂₈F₃NO₂
Molecular Weight:443.509
Hs Code.:

Synonyms:(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

Chemical Property:

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Technology Process of (1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

There total 4 articles about (1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 868166-22-7
1-[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methanamine

: 20780-54-5
(S)-styrene oxide

: 1286204-54-3
(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

Guidance literature:: In isopropyl alcohol; at 75 ℃; for 15h; Sealed tube;
DOI:10.1021/ml100309n

Reference yield:

: 868166-20-5
2-iodo-5-(trifluoromethyl)benzonitrile

: 1286204-54-3
(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 2-Methyl-1,2-propanediol; ethanol; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

1.2: 0.17 h / 150 °C / Microwave irradiation

2.1: lithium aluminium tetrahydride / diethyl ether / 6 h / 0 - 20 °C

3.1: isopropyl alcohol / 15 h / 75 °C / Sealed tube

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 2-Methyl-1,2-propanediol; diethyl ether; ethanol; water; isopropyl alcohol;
DOI:10.1021/ml100309n

Reference yield:

: 6526-08-5
2-amino-5-(trifluoromethyl)benzonitrile

: 1286204-54-3
(1R)-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)-1-phenylethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butylnitrite; diiodomethane / 0.5 h / 100 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 2-Methyl-1,2-propanediol; ethanol; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

2.2: 0.17 h / 150 °C / Microwave irradiation

3.1: lithium aluminium tetrahydride / diethyl ether / 6 h / 0 - 20 °C

4.1: isopropyl alcohol / 15 h / 75 °C / Sealed tube

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; diiodomethane; sodium carbonate; In 2-Methyl-1,2-propanediol; diethyl ether; ethanol; water; isopropyl alcohol;
DOI:10.1021/ml100309n