[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

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Chemical Name:[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester
CAS No.:195711-68-3
Molecular Formula:C₄₃H₅₈N₆O₉
Molecular Weight:802.968
Hs Code.:

[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

Synonyms:[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

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Chemical Property of [(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

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Technology Process of [(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

There total 6 articles about [(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 73278-98-5
N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine

: 4-[3-(3-{[tert-Butoxycarbonylmethyl-(3-methoxy-phenyl)-carbamoyl]-methyl}-ureido)-benzyloxycarbonylamino]-butyric acid

: 195711-68-3
[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 195711-68-3
[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 5 min, 2.) THF, RT, 30 min

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 5.56 g / aq. K₂CO₃ / methanol / 16 h / Ambient temperature

5: 77 percent / HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

: 195711-92-3
[(3-methoxyphenylcarbamoyl)methyl]carbamic acid

: 195711-68-3
[(3-methoxyphenyl)-({3-[3-({3-[3-(3-piperidin-1-ylmethylphenoxy)propylcarbamoyl]propyl}carbamoyloxymethyl)phenyl]ureido}acetyl)amino]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 5 min, 2.) THF, RT, 30 min

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 5.56 g / aq. K₂CO₃ / methanol / 16 h / Ambient temperature

5: 77 percent / HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00076-X