((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

Base Information

Chemical Name:((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid
CAS No.:195711-79-6
Molecular Formula:C₃₉H₅₀N₆O₉
Molecular Weight:746.861
Hs Code.:

((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

Synonyms:((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

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Chemical Property of ((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

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Technology Process of ((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

There total 7 articles about ((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73278-98-5
N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine

: 195711-79-6
((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

2: 8.60 g / TFA, anisole / CH₂Cl₂ / 16 h / Ambient temperature

With benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

: 195711-92-3
[(3-methoxyphenylcarbamoyl)methyl]carbamic acid

: 195711-79-6
((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) THF, 5 min, 2.) THF, RT, 30 min

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 5.56 g / aq. K₂CO₃ / methanol / 16 h / Ambient temperature

5: 77 percent / HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

6: 8.60 g / TFA, anisole / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00076-X

Reference yield:

: 195711-94-5
[benzyloxycarbonylaminoacetyl-(3-methoxyphenyl)amino]acetic acid tert-butyl ester

: 195711-79-6
((3-Methoxy-phenyl)-{2-[3-(3-{3-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylcarbamoyl]-propylcarbamoyloxymethyl}-phenyl)-ureido]-acetyl}-amino)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 5.56 g / aq. K₂CO₃ / methanol / 16 h / Ambient temperature

4: 77 percent / HOBt, Et₃N, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 16 h / Ambient temperature

5: 8.60 g / TFA, anisole / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogen; potassium carbonate; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00076-X