1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

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Chemical Name:1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid
CAS No.:1307809-53-5
Molecular Formula:C₂₈H₂₄F₃N₃O₄
Molecular Weight:523.511
Hs Code.:

Synonyms:1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

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Chemical Property of 1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

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Technology Process of 1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

There total 12 articles about 1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.9%

: 1307812-32-3
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1307809-53-5
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde; 3-azetidinecarboxylic acid; With acetic acid; In methanol; 1,2-dichloro-ethane; at 60 ℃; for 1h;

With sodium cyanoborohydride; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307809-53-5
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 7 h / 20 °C

6.2: 20 °C

7.1: acetic acid / 1,2-dichloro-ethane; methanol / 1 h / 60 °C

7.2: 0.5 h / 20 °C

With N-chloro-succinimide; osmium(VIII) oxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 23203-51-2
6-methoxy-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one

: 1307809-53-5
1-((5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron tribromide / dichloromethane / 0 °C

2.1: pyridine / 3.58 h / 20 °C / Cooling with ice

3.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C / Sealed tube; Inert atmosphere

4.1: sodium acetate / methanol / 1.5 h / Reflux

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 7 h / 20 °C

6.2: 20 °C

7.1: acetic acid / 1,2-dichloro-ethane; methanol / 1 h / 60 °C

7.2: 0.5 h / 20 °C

With osmium(VIII) oxide; sodium acetate; boron tribromide; acetic acid; 4-methylmorpholine N-oxide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; 1,2-dichloro-ethane;