5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Base Information

Chemical Name:5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde
CAS No.:1307812-32-3
Molecular Formula:C₂₄H₁₇F₃N₂O₃
Molecular Weight:438.406
Hs Code.:

Synonyms:5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

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Chemical Property of 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

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Technology Process of 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

There total 11 articles about 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1307812-31-2
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

: 1307812-32-3
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃; for 7h;

With sodium periodate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307812-32-3
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 7 h / 20 °C

6.2: 20 °C

With N-chloro-succinimide; osmium(VIII) oxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 23203-51-2
6-methoxy-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one

: 1307812-32-3
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 0 °C

2.1: pyridine / 3.58 h / 20 °C / Cooling with ice

3.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C / Sealed tube; Inert atmosphere

4.1: sodium acetate / methanol / 1.5 h / Reflux

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 7 h / 20 °C

6.2: 20 °C

With osmium(VIII) oxide; sodium acetate; boron tribromide; 4-methylmorpholine N-oxide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water;