N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

Base Information

Chemical Name:N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide
CAS No.:1609152-86-4
Molecular Formula:C₂₀H₂₃Cl₂N₃O₄
Molecular Weight:440.326
Hs Code.:

Synonyms:N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

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Chemical Property of N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

Chemical Property:

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Technology Process of N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

There total 5 articles about N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 110-91-8,99108-56-2
morpholine

: 1185160-66-0
3-(3-chloropropox y)-N-(3,5-dichloropyridin-4-yl) - 4-methoxybenzamine

: 1609152-86-4
N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

Guidance literature:: 3-(3-chloropropox y)-N-(3,5-dichloropyridin-4-yl) - 4-methoxybenzamine; With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

morpholine; In N,N-dimethyl-formamide; at 75 ℃; for 10h;
DOI:10.3184/174751913X13782291519608

Reference yield:

: 3-(3-chloropropoxy)-4-methoxybenzoic acid

: 1609152-86-4
N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 5 h / 15 - 25 °C

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 10 h / 75 °C

With thionyl chloride; sodium hydride; potassium carbonate; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3184/174751913X13782291519608

Reference yield:

: 929683-54-5
3-(3-chloropropoxy)-4-methoxybenzaldehyde

: 1609152-86-4
N-(3,5-dichloropyridin-4-yl)-4-methoxy-3-(3-morpholinopropoxy)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: aminosulfonic acid; acetic acid; sodium chlorite / water / 1 h / 0 - 5 °C / Cooling with ice

2.1: thionyl chloride / 2 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 5 h / 15 - 25 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 10 h / 75 °C

With sodium chlorite; thionyl chloride; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.3184/174751913X13782291519608