3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

Base Information

Chemical Name:3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid
CAS No.:1401461-67-3
Molecular Formula:C₂₃H₁₉N₅O₃S
Molecular Weight:445.502
Hs Code.:

Synonyms:3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

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Chemical Property of 3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

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Technology Process of 3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

There total 6 articles about 3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1401462-39-2
methyl 3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate

: 1401461-67-3
3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

Guidance literature:: methyl 3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoate; With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; water;

Reference yield:

: 1045709-32-7,1254966-66-9
bis(2-oxa-6-azaspiro[3.3]heptan-6-ium) ethanedioate

: 1401461-67-3
3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / Inert atmosphere; Reflux

5: sodium hydroxide; methanol / tetrahydrofuran / 15 h / 20 °C

With methanol; hydrogen; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1522-92-5
2,2-bis(bromomethyl)-3-bromo-propan-1-ol

: 1401461-67-3
3-(7-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenylamino)thiazolo[5,4-d]pyrimidin-5-yl)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide / ethanol / 45 h / Reflux

2: magnesium / methanol

3: caesium carbonate; XPhos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Inert atmosphere; Reflux

4: hydrogen / palladium 10% on activated carbon / ethanol / 15 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 16 h / 20 °C

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / Inert atmosphere; Reflux

7: sodium hydroxide; methanol / tetrahydrofuran / 15 h / 20 °C

With methanol; hydrogen; sodium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; XPhos; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;