1522-92-5

Usage

Uses

Used in Flame Retardancy:
3-Bromo-2,2-bis(bromomethyl)propanol is used as a flame retardant in various industries due to its brominated nature, which helps to slow down the spread of fire and reduce the risk of ignition.
Used in Plastics and Polymers Industry:
In the plastics and polymers industry, 3-Bromo-2,2-bis(bromomethyl)propanol is used as an additive to enhance the fire resistance of materials, making them safer for use in various applications where fire hazards are a concern.
Used in Textile Industry:
3-Bromo-2,2-bis(bromomethyl)propanol is also utilized in the textile industry to improve the flame retardancy of fabrics, providing an additional layer of safety in products such as upholstery, curtains, and other home furnishings.
Used in Electronic Industry:
In the electronic industry, 3-Bromo-2,2-bis(bromomethyl)propanol is employed as a component in the manufacturing of flame-resistant materials for electronic devices and components, reducing the risk of fire damage in case of electrical faults or overheating.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A brominated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Fire Hazard

The flash point of 3-Bromo-2,2-bis(bromomethyl)propanol has not been determined, but 3-Bromo-2,2-bis(bromomethyl)propanol is probably combustible.

InChI:InChI=1/C5H9Br3O/c1-4(2,3-9)5(6,7)8/h9H,3H2,1-2H3

Upstream product

• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 115-77-5 Pentaerythritol 
• 10035-10-6 hydrogen bromide 
• 64-19-7 acetic acid 
• 3580-97-0 3-bromo-2,2-bis(bromomethyl)propyl acetate 

Downstream Products

• 338-61-4 3,3-bis-fluoromethyl-oxetane 
• 400-11-3 3-fluoro-2-fluoromethyl-1-propene 
• 2402-83-7 3,3-bis(bromomethyl)oxetane 
• 52813-48-6 3-bromo-2,2-bis(bromomethyl)propanoic acid 
• 14205-58-4 1-benzenesulfonyloxy-3-bromo-2,2-bis-bromomethyl-propane 
• 174-79-8 2,6-dioxaspiro<3.3>heptane 
• 22633-44-9 [3-(bromomethyl)oxetan-3-yl]methanol 
• 723294-39-1 C₃₄H₅₆O₁₁ 
• 723294-40-4 C₄₀H₆₈O₁₄ 
• 2831-90-5 α,α,α-tris(hydroxymethyl)acetic acid 
• 99853-46-0 3-bromo-2,2-bis-bromomethyl-1-phenyl-propan-1-one 
• 100119-06-0 3-bromo-2,2-bis-bromomethyl-1-p-tolyl-propan-1-one 
• 99859-58-2 3-bromo-2,2-bis-bromomethyl-propionic acid anilide 
• 99853-47-1 3-bromo-2,2-bis-bromomethyl-propionic acid phenyl ester 

Relevant academic research and scientific papers

Synthesis and copolymerization of azidomethyl-substituted oxetanes: the morphology of statistical block copolymers

[Figure not available: see fulltext.] 3,3-Bis(azidomethyl)oxetane and 3-azidomethyl-3-methyloxetane were obtained by bromination of pentaerythritol and metriol with a mixture of hydrobromic, acetic, and sulfuric acids, followed by cyclization in the presence of a phase-transfer catalyst TBAB, with the formation of oxetane ring and replacement of bromide substituents with azide ions. The copolymerization reaction of 3,3-bis-(azidomethyl)oxetane and 3-azidomethyl-3-methyloxetane was performed in the presence of a catalytic system prepared from triisobutylaluminum and water. The methods of small-angle and wide-angle X-ray diffraction analysis were used to determine the amorphous-crystalline and domain structures of the synthesized copolymers. We also present data about conformational and relaxation transitions in these statistical copolymers.

Altering the specificity of subtilisin Bacillus lentus through the introduction of positive charge at single amino acid sites

The use of methanethiosulfonates as thiol-specific modifying reagents in the strategy of combined site-directed mutagenesis and chemical modification allows virtually unlimited opportunities for creating new protein surface environments. As a consequence

Monosialoside with multimer-like anti-influenza potency

Synthetic glycopeptides capable of assembling in aqueous solution demonstrated enhanced influenza virus blocking potency.

Preparation method of 1-hydroxymethylcyclopropyl acetonitrile

The present invention relates to a method for preparing 1-hydroxymethylcyclopropyl acetonitrile, which belongs to the field of pharmaceutical intermediate synthesis technology. The present invention takes pentaerythritol as raw material, after bromination reaction to give tribromo neoamyl alcohol, and then by acetylation reaction to give 3-bromo-2,2-bis (bromomethyl) propyl acetate, the starting material is selected pentaerythritol, the reaction temperature is reduced from 90 ° C to 50 ° C, the reaction time is shortened from about 35 hours to about 10 hours, shortening the reaction time, reducing the reaction temperature, greatly reducing the production cost; the use of bromine-containing materials in the reaction process, to achieve the recovery of bromine elements, greatly reducing the output of waste, At the same time, it also solves the problem that cyclopropyl dimethylol contains two hydroxyl groups, only one hydroxyl group needs to be protected; further, the present invention uses a cyanide solution instead of a cyanide solid, reducing the risk of direct contact between the operator and the cyanide-containing material. The raw materials used in the present invention are simple and readily available, the process flow is simple, suitable for industrial large-scale production.

Preparation method of trisbromoneopentyl alcohol

The invention provides a preparation method of trisbromoneopentyl alcohol. The method taking pentaerythritol, bromine and sulfur powder as raw materials comprises the following steps: reducing bromineby taking the sulfur powder as a reducing agent to generate hydrogen bromide in situ, carrying out a heating reaction on the hydrogen bromide and an organic acid used as a solvent, carrying out reduced pressure distillation after the reaction is finished to recover acetic acid and hydrogen bromide, performing alcoholysis by using methanol, carrying out reduced pressure distillation to recover methanol and methyl acetate, adding an aqueous sodium carbonate solution to neutralize generated sulfuric acid, adding water and alkane, performing liquid separation, and performing cooling crystallization on the obtained organic phase to obtain high-purity trisbromoneopentyl alcohol. Compared with preparation methods which are publicly reported at present, the preparation method for preparing the trisbromoneopentyl alcohol from hydrogen bromide generated in situ by reducing bromine with the sulfur powder has the advantages of few side reactions, low cost, high yield of 90% or above, realizationof the product purity of 99.5% or above, simplicity in operation, and facilitation of industrial production.

Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action

Generation of dimers, trimers and dendrimers of bioactive compounds is an approach that has recently been developed for the discovery of new potent drug candidates. Herein, we present the synthesis of new artemisinin-derived dimers and dendrimers and inve

A three-the bromine is new pentanol synthetic method

The invention relates to a synthetic method of trisbromoneopentyl alcohol. The synthetic method comprises: adding pentaerythritol in an inert solvent; adding phosphorous tribromide for substitution reaction; performing under-pressure distillation to remove the solvent after the reaction is over and obtaining trisbromoneopentyl alcohol ester; adding methanol into trisbromoneopentyl alcohol ester for transesterification; performing distillation to remove redundant methanol after transesterification is over; washing the obtained product till the pH value of a filtering liquid is 7 to obtain crude trisbromoneopentyl alcohol; and performing recrystallization of crude trisbromoneopentyl alcohol by using a mixed solvent of methanol and water to obtain pure trisbromoneopentyl alcohol. Compared to a conventional synthetic method, the method in the invention has characteristics, such as available raw materials, simple preparation technology, high synthetic yield, and less by-product.

Synthesis and structural characterization of ruthenium(II) complexes bearing phosphine-pyrazolyl based tripod ligands

Phosphine-pyrazolyl based tripod ligands ROCH2C(CH2Pz)2(CH2PPh2) (R = H, Me, allyl; Pz = pyrazol-1-yl) were efficiently synthesized and characterized. Reactions of these ligands with [Ru(η6-p-cymene)Cl2]2 afforded complexes of the type [Ru(η6-p-cymene)Cl2](L) (6-8) in which the ligands exhibit κ1-P-coordination to the metal center. Complex [Ru(η6-p-cymene)Cl2{Ph2PCH2C(CH2OH)(CH2Pz)2}] (6) underwent chloride-dissociation in CH2Cl2/MeCN to give complex [RuCl(η6-p-cymene){κ2(P,N)-Ph2PCH2C(CH2OH)(CH2Pz)2}][Cl] (9). Complexes 6-9 demonstrated poor to moderate catalytic activity in the transfer hydrogenation of acetophenone. All these complexes were fully characterized by analytical and spectroscopic methods and their molecular structures were determined by X-ray crystallographic study.

Synthesis and characterization of pentaerythritol-derived oligoglycol and their application to catalytic Wittig-type reactions

Several pentaerythritol-derived oligoglycols 1 with free hydroxyl groups are readily prepared by a convergent approach. Quantitative 13C NMR proves to be an efficient tool for the characterization of oligoglycols. The corresponding telluride of oligoglycol 17 is synthesized and used as a good catalyst for Wittig-type reactions in preparing both disubstituted and trisubstituted olefins in good to high yields.

Chemically modified enzymes with multiple charged variants

This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol