ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

Base Information

Chemical Name:ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate
CAS No.:174774-17-5
Molecular Formula:C₂₈H₃₂N₄O₆
Molecular Weight:520.585
Hs Code.:

Synonyms:ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

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Chemical Property of ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

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Technology Process of ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

There total 9 articles about ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 174774-65-3
5-(benzyloxycarbonylamidino)-2-benzofurancarboxylic acid

: 174774-89-1
ethyl 3-(4-aminopiperidino)propionate

: 174774-17-5
ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

Guidance literature:: With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1248/cpb.47.1694

Reference yield:

: 41661-47-6
piperidin-4-one

: 174774-17-5
ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / K₂CO₃ / dimethylformamide

2: 74 percent / sodium cyanoborohydride; CH₃COOH / ethanol / 18 h / 20 °C / pH 6 - 7

3: 81 percent / H₂ / 10 percent Pd/C / ethanol / 5 h / Heating

4: 69 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

With hydrogen; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; acetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: Alkylation / 2: reductive amination / 3: Hydrogenolysis / 4: coupling;
DOI:10.1248/cpb.47.1694

Reference yield:

: 174774-90-4
ethyl 3-(4-oxopiperidin-1-yl)propanoate

: 174774-17-5
ethyl 3-[4-[(5-benzyloxycarbonylamidino)benzofuran-2-carboxamido]piperidino]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / sodium cyanoborohydride; CH₃COOH / ethanol / 18 h / 20 °C / pH 6 - 7

2: 81 percent / H₂ / 10 percent Pd/C / ethanol / 5 h / Heating

3: 69 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

With hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: reductive amination / 2: Hydrogenolysis / 3: coupling;
DOI:10.1248/cpb.47.1694