(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

Base Information

Chemical Name:(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate
CAS No.:1141364-91-1
Molecular Formula:C₂₆H₃₉NO₇S
Molecular Weight:509.664
Hs Code.:

Synonyms:(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

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Chemical Property of (1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

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Technology Process of (1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

There total 5 articles about (1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (3R,4R)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1,4-dicarboxylate

: 106-45-6
para-thiocresol

: 1141364-91-1
(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

Guidance literature:: With caesium carbonate; In ethanol; at -15 ℃; for 36h; Inert atmosphere;
DOI:10.1002/chem.201001108

Reference yield: 71.0%

: (3R,4R)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)cyclohex-1-ene-1,4-dicarboxylate

: 106-45-6
para-thiocresol

: 1141364-91-1
(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

: 1197988-95-6
(3S,4R)-4-tert-butyl 1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

Guidance literature:: With triethylamine; In ethanol; at 23 ℃; for 12h;
DOI:10.1002/chem.201001108

Reference yield:

: 20345-61-3
ethyl 2-diethoxyphosphinoylacrylate

: 1141364-90-0
2-(pentan-3-yloxy)acetaldehyde

: 106-45-6
para-thiocresol

: 537005-95-1
(E)-tert-butyl 3-nitroprop-2-enoate

: 1141364-91-1
(1S,2R,3S,4R,5S)-4-tert-butyl-1-ethyl-5-nitro-3-(pentan-3-yloxy)-2-(p-tolylthio)cyclohexane-1,4-dicarboxylate

Guidance literature:: 2-(pentan-3-yloxy)acetaldehyde; (E)-tert-butyl 3-nitroprop-2-enoate; With (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; chloroacetic acid; In toluene; at 23 ℃; for 6h; Inert atmosphere;

ethyl 2-diethoxyphosphinoylacrylate; With caesium carbonate; In toluene; at 23 ℃; for 2h; Inert atmosphere;

para-thiocresol; optical yield given as %ee; enantioselective reaction; Further stages;
DOI:10.1002/ejoc.201100074