11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester

Base Information

• Chemical Name: 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester
• CAS No.: 113461-96-4
• Molecular Formula: C₃₇H₅₀N₂O₉
• Molecular Weight: 666.812

Synonyms:11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester

Chemical Property of 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester

Chemical Property:

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Technology Process of 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester

There total 6 articles about 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-13-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine-11-carboxylic acid isopropyl ester (113461-91-9) → 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-13-carboxylic acid isopropyl ester (113461-96-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 34h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00253a022

Reference yield:

(Z)-4-benzyl-1-<(isopropyloxy)carbonyl>-6-<2,4,5-trimethoxy-3-methylphenyl)methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione (113479-98-4) → 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-13-carboxylic acid isopropyl ester (113461-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 1 h / 0 °C

2: 60 percent / HCOOH / 1 h / 60 °C

3: 87 percent / H₂ / PtO₂ / ethanol / 24 h / 25 °C

With formic acid; lithium tri(t-butoxy)aluminum hydride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol;

DOI:10.3987/R-1987-07-1765

Reference yield:

(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione (113461-80-6) → 11-Cyclohexylmethyl-3,4,6-trimethoxy-5-methyl-10-oxo-12-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(E)-ylidene]-11,13-diaza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-triene-13-carboxylic acid isopropyl ester (113461-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 25 °C

2: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

3: 87 percent / H₂ / PtO₂ / ethyl acetate / 34 h / 760 Torr / Ambient temperature

With dmap; formic acid; lithium tri(t-butoxy)aluminum hydride; hydrogen; triethylamine; platinum(IV) oxide; In dichloromethane; ethyl acetate;

DOI:10.1021/jo00253a022

upstream raw materials:

(E)-3-benzyl-2-<(2,4,5-trimethoxy-3-methylphenyl)-methylene>-7,9,10-trimethoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine-11-carboxylic acid isopropyl ester

(Z)-4-benzyl-1-<(isopropyloxy)carbonyl>-6-<2,4,5-trimethoxy-3-methylphenyl)methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

4-Benzyl-2-hydroxy-5-oxo-6-(2,4,5-trimethoxy-3-methyl-benzyl)-3-[1-(2,4,5-trimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-1-carboxylic acid isopropyl ester

(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

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