tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Base Information

Chemical Name:tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate
CAS No.:1386981-11-8
Molecular Formula:C₃₇H₄₆ClN₉O₅
Molecular Weight:732.283
Hs Code.:

tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Synonyms:tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Chemical Property of tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Technology Process of tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

There total 12 articles about tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4572-03-6
3-(N-methylpiperazino)propylamine

: 1386981-13-0
tert-butyl 3-(4-chloro-3-(2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

: 1386981-11-8
tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 1386980-94-4
tert-butyl 3-(4-chloro-3-(2-(methylthio)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

: 1386981-11-8
tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / water; tetrahydrofuran; methanol / 20 °C

2: N,N-dimethyl-formamide / 2 h / 80 °C

With Oxone; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 1386981-11-8
tert-butyl 3-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 6 h / 65 °C

5.1: triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 18 h / 20 °C

6.1: Oxone / water; tetrahydrofuran; methanol / 20 °C

7.1: N,N-dimethyl-formamide / 2 h / 80 °C

With Oxone; lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;