N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

Base Information

Chemical Name:N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide
CAS No.:1403828-85-2
Molecular Formula:C₂₀H₂₅BrF₃NO₃
Molecular Weight:464.323
Hs Code.:

Synonyms:N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

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Chemical Property of N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

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Technology Process of N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

There total 2 articles about N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1403828-84-1
(2-bromocyclohex-2-enyl)[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]amine

: 407-25-0
trifluoroacetic anhydride

: 1403828-85-2
N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1002/anie.201205403

Reference yield:

: 1403828-83-0
2-(2-bromocyclohex-2-enylamino)-2-methylpropan-1-ol

: 1403828-85-2
N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2: pyridine / dichloromethane / 6 h / 20 °C

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201205403

Reference yield:

: 1403828-85-2
N-(2-bromocyclohex-2-enyl)-2,2,2-trifluoro-N-[2-(4-methoxybenzyloxy)-1,1-dimethylethyl]acetamide

: 2,2,2-trifluoro-1-[2-(4-methoxybenzyloxymethyl)-2-methyl-2,3,5,6,7,7a-hexahydroindol-1-yl]-ethanone

: 2,2,2-trifluoro-1-[2-(4-methoxybenzyloxymethyl)-2-methyl-2,3,5,6,7,7a-hexahydroindol-1-yl]-ethanone

Guidance literature:: With rubidium carbonate; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In toluene; at 20 - 120 ℃; Overall yield = 53 %; Overall yield = 44 mg;
DOI:10.1002/anie.201205403