3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

Base Information

Chemical Name:3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate
CAS No.:915750-78-6
Molecular Formula:C₁₉H₁₉F₃O₄
Molecular Weight:368.353
Hs Code.:

Synonyms:3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

Chemical Property:

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Technology Process of 3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

There total 4 articles about 3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5445-17-0
Methyl 2-bromopropionate

: 6185-76-8
(4-methoxyphenyl)(4-(trifluoromethyl)phenyl)methanone

: 915750-78-6
3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

Guidance literature:: With iodine; zinc; In diethyl ether; benzene; for 48h; Heating;
DOI:10.1016/j.tet.2006.07.106

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 915750-78-6
3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; I₂ / diethyl ether / 2 h / Heating

1.2: 75 percent / tetrahydrofuran / Heating

2.1: 70 percent / Jones reagent / acetone / 0 °C

3.1: 80 percent / activated Zn; I₂ / benzene; diethyl ether / 48 h / Heating

With jones reagent; iodine; magnesium; zinc; In diethyl ether; acetone; benzene; 1.2: Grignard reaction / 3.1: Reformatsky reaction;
DOI:10.1016/j.tet.2006.07.106

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 915750-78-6
3-(p-methoxyphenyl)-3-[(p-trifluoromethyl)phenyl]-3-hydroxy-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; I₂ / diethyl ether / 2 h / Heating

1.2: 75 percent / tetrahydrofuran / Heating

2.1: 70 percent / Jones reagent / acetone / 0 °C

3.1: 80 percent / activated Zn; I₂ / benzene; diethyl ether / 48 h / Heating

With jones reagent; iodine; magnesium; zinc; In diethyl ether; acetone; benzene; 1.2: Grignard reaction / 3.1: Reformatsky reaction;
DOI:10.1016/j.tet.2006.07.106