ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate

Base Information

• Chemical Name: ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate
• CAS No.: 934548-28-4
• Molecular Formula: C₁₉H₂₁BrN₂O₅S
• Molecular Weight: 469.356
• Mol file: 934548-28-4.mol

Synonyms:ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate

Chemical Property of ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate

There total 3 articles about ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

ethyl (2-bromo-6-methoxy-4-methylphenyl)-2-oxoacetate (934548-27-3) + toluene-4-sulfonic acid hydrazide (1576-35-8) → ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate (934548-28-4) + ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate

Guidance literature:

In ethanol; at 50 ℃; for 43h;

DOI:10.1016/j.tet.2007.01.010

Reference yield:

2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile (934548-26-2) → ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate (934548-28-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / LiHMDS / tetrahydrofuran / 2 h / -78 °C

2: 54 percent / ethanol / 43 h / 50 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2007.01.010

Reference yield:

2-bromo-6-methoxy-4-methylbenzaldehyde (133129-29-0) → ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate (934548-28-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / benzyltrimethylammonium chloride; 18-crown-6 / 1,2-dichloro-ethane; H₂O / 15 h / 50 °C

2: 91 percent / LiHMDS / tetrahydrofuran / 2 h / -78 °C

3: 54 percent / ethanol / 43 h / 50 °C

With 18-crown-6 ether; benzyltrimethylammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; 1,2-dichloro-ethane;

DOI:10.1016/j.tet.2007.01.010

upstream raw materials:

ethyl (2-bromo-6-methoxy-4-methylphenyl)-2-oxoacetate

toluene-4-sulfonic acid hydrazide

2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile

2-bromo-6-methoxy-4-methylbenzaldehyde

Downstream raw materials:

ethyl 4-methoxy-6-methyl-1-(4-methylphenylsulfonyl)indazole-3-carboxylate