2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile

Base Information

• Chemical Name: 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile
• CAS No.: 934548-26-2
• Molecular Formula: C₁₃H₁₄BrNO₄
• Molecular Weight: 328.162
• Mol file: 934548-26-2.mol

Synonyms:2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile

Chemical Property of 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile

There total 1 articles about 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

potassium cyanide (151-50-8) + chloroformic acid ethyl ester (541-41-3) + 2-bromo-6-methoxy-4-methylbenzaldehyde (133129-29-0) → 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile (934548-26-2)

Guidance literature:

With 18-crown-6 ether; benzyltrimethylammonium chloride; In water; 1,2-dichloro-ethane; at 50 ℃; for 15h;

DOI:10.1016/j.tet.2007.01.010

Reference yield: 91.0%

2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile (934548-26-2) → ethyl (2-bromo-6-methoxy-4-methylphenyl)-2-oxoacetate (934548-27-3)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1016/j.tet.2007.01.010

Reference yield:

2-(2-bromo-6-methoxy-4-methylphenyl)-2-(ethoxycarbonyloxy)acetonitrile (934548-26-2) → ethyl 4-methoxy-6-methyl-1-(4-methylphenylsulfonyl)indazole-3-carboxylate (934548-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / LiHMDS / tetrahydrofuran / 2 h / -78 °C

2: 54 percent / ethanol / 43 h / 50 °C

3: 50 percent / LiHMDS / Pd(OAc)2; dppf / tetrahydrofuran; dioxane / 66 h / 20 °C

With lithium hexamethyldisilazane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1016/j.tet.2007.01.010

upstream raw materials:

potassium cyanide

chloroformic acid ethyl ester

2-bromo-6-methoxy-4-methylbenzaldehyde

Downstream raw materials:

ethyl (2-bromo-6-methoxy-4-methylphenyl)-2-oxoacetate

ethyl 4-methoxy-6-methyl-1-(4-methylphenylsulfonyl)indazole-3-carboxylate

ethyl 2-(2-bromo-6-methoxy-4-methylphenyl)-2-(4-methylphenylsulfonyl)hydrazonacetate