(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane

Base Information

• Chemical Name: (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane
• CAS No.: 289889-72-1
• Molecular Formula: C₂₃H₂₄F₃NO₃
• Molecular Weight: 419.444
• Mol file: 289889-72-1.mol

Synonyms:(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane

Chemical Property of (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane

There total 1 articles about (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-trifluoroacetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (111381-04-5) + (4-phenylbut-1-yn-1-yl)copper → (+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane (289889-72-1)

Guidance literature:

With pyridine; at 120 ℃;

DOI:10.1021/jm9906062

Reference yield: 46.0%

(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane (289889-72-1) → (+/-)-N-trifluoro-2-[2,5-dimethoxy-4-(4-phenylbutyl)phenyl]-2-aminopropane (289889-74-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; under 2068.59 Torr;

DOI:10.1021/jm9906062

Reference yield:

(+/-)-N-trifluoroacetyl-1-[2,5-dimethoxy-4-(4-phenyl-1-butynyl)phenyl]-2-aminopropane (289889-72-1) → 2-[2,5-dimethoxy-4-(4-phenyl-butyl)-phenyl]-1-methyl-ethylamine

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / H₂ / 10 percent Pd/C / methanol / 4 h / 2068.59 Torr

2: 18 percent / 15 percent aq. NaOH / methanol / 2 h / Heating

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; 1: Catalytic hydrogenation / 2: Hydrolysis;

DOI:10.1021/jm9906062

upstream raw materials:

N-trifluoroacetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

Downstream raw materials:

(+/-)-N-trifluoro-2-[2,5-dimethoxy-4-(4-phenylbutyl)phenyl]-2-aminopropane