2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

Base Information

Chemical Name:2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester
CAS No.:380412-95-3
Molecular Formula:C₁₈H₁₈N₂O₇S
Molecular Weight:406.416
Hs Code.:

Synonyms:2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

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Chemical Property of 2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

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Technology Process of 2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

There total 10 articles about 2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 147162-34-3
2-Allyl-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

: 380412-95-3
2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

Guidance literature:: 2-Allyl-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 20 ℃;
DOI:10.1139/v01-100

Reference yield:

: 35500-75-5
(1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one

: 380412-95-3
2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C

2.1: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C

3.1: ozone / CH₂Cl₂; methanol / -78 °C

3.2: 100 percent / dimethyl sulfide / CH₂Cl₂; methanol / -78 - 20 °C

With N-benzyl-trimethylammonium hydroxide; ozone; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v01-100

Reference yield:

: 380412-94-2
3-methyl-2-((1R)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-2-enoic acid methyl ester

: 380412-95-3
2-(2-Oxo-ethyl)-2-((1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / potassium permanganate; magnesium sulfate / H₂O; ethanol

2.1: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C

3.1: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C

4.1: ozone / CH₂Cl₂; methanol / -78 °C

4.2: 100 percent / dimethyl sulfide / CH₂Cl₂; methanol / -78 - 20 °C

With potassium permanganate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; ozone; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1139/v01-100