tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

Base Information

Chemical Name:tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate
CAS No.:220280-79-5
Molecular Formula:C₂₀H₂₉N₃O₄
Molecular Weight:375.468
Hs Code.:

Synonyms:tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

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Chemical Property of tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

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Technology Process of tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

There total 6 articles about tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92841-65-1
(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one

: 220280-79-5
tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / acetonitrile / 4 h / 80 °C

2.1: 87 percent / NaN₃ / acetonitrile / 72 h / 80 °C

3.1: 100 percent / H₂; HCl / Pd/C / methanol; H₂O

4.1: 68 percent / CH₂Cl₂ / 24 h / 20 °C

5.1: DBU; LiCl / acetonitrile / 18 h / -20 °C

5.2: HCl / H₂O

With hydrogenchloride; sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile; 1.1: Substitution / 2.1: Substitution / 3.1: Catalytic hydrogenation / 4.1: Condensation / 5.1: Addition / 5.2: Hydrolysis;
DOI:10.1021/jo000321t

Reference yield:

: 143359-25-5
(4S,5R)-(-)-(2'-chloroacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone

: 220280-79-5
tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / NaN₃ / acetonitrile / 72 h / 80 °C

2.1: 100 percent / H₂; HCl / Pd/C / methanol; H₂O

3.1: 68 percent / CH₂Cl₂ / 24 h / 20 °C

4.1: DBU; LiCl / acetonitrile / 18 h / -20 °C

4.2: HCl / H₂O

With hydrogenchloride; sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile; 1.1: Substitution / 2.1: Catalytic hydrogenation / 3.1: Condensation / 4.1: Addition / 4.2: Hydrolysis;
DOI:10.1021/jo000321t

Reference yield:

: 307304-37-6
(4S,5R)-(-)-1-(2'-azidoacetyl)-3,4-dimethyl-5-phenyl-2-imidazolidinone

: 220280-79-5
tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂; HCl / Pd/C / methanol; H₂O

2.1: 68 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: DBU; LiCl / acetonitrile / 18 h / -20 °C

3.2: HCl / H₂O

With hydrogenchloride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; palladium on activated charcoal; In methanol; dichloromethane; water; acetonitrile; 1.1: Catalytic hydrogenation / 2.1: Condensation / 3.1: Addition / 3.2: Hydrolysis;
DOI:10.1021/jo000321t