Technology Process of (5S)-N-[3-(2-fluoro-4'-{[(1H-[1,2,3]triazol-4-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-oxazolidin-5-ylmethyl]acetamide hydrochloride
There total 8 articles about (5S)-N-[3-(2-fluoro-4'-{[(1H-[1,2,3]triazol-4-ylmethyl)amino]methyl}biphenyl-4-yl)-2-oxo-oxazolidin-5-ylmethyl]acetamide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol; ethyl acetate;
at 20 ℃;
for 8h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 12.5 h / -78 - 25 °C / Inert atmosphere
2.1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 25 °C
3.1: triethylamine / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide / 2 h / 25 - 70 °C
5.1: hydrazine hydrate / ethanol / 2 h / 25 °C / Reflux
6.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere
7.1: toluene / 21 h / 25 - 110 °C
7.2: 0.17 h / 25 °C
8.1: hydrogenchloride / 1,4-dioxane; ethyl acetate; methanol / 8 h / 25 °C
With
hydrogenchloride; dmap; N-iodo-succinimide; n-butyllithium; hydrazine hydrate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / water; tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: 12.5 h / -78 - 25 °C / Inert atmosphere
3.1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 25 °C
4.1: triethylamine / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide / 2 h / 25 - 70 °C
6.1: hydrazine hydrate / ethanol / 2 h / 25 °C / Reflux
7.1: triethylamine; dmap / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere
8.1: toluene / 21 h / 25 - 110 °C
8.2: 0.17 h / 25 °C
9.1: hydrogenchloride / 1,4-dioxane; ethyl acetate; methanol / 8 h / 25 °C
With
hydrogenchloride; dmap; N-iodo-succinimide; n-butyllithium; potassium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;