dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

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Chemical Name:dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate
CAS No.:221077-41-4
Molecular Formula:C₂₅H₃₄N₂O₉
Molecular Weight:506.553
Hs Code.:

Synonyms:dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

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Chemical Property of dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

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Technology Process of dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

There total 3 articles about dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 762-42-5
dimethyl acetylenedicarboxylate

: 221077-39-0
methyl 4-{[(1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethyl]amino}-4-oxobutanoate

: 221077-41-4
dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/jm010393s

Reference yield:

: 110-58-7
n-Pentylamine

: 221077-41-4
dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / CH₂Cl₂ / 23 h / 20 °C

2: 100 percent / HCl / dioxane / 1.5 h / 20 °C

3: EDC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

4: 79 percent / Et₃N / tetrahydrofuran / 50 °C

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm010393s

Reference yield:

: 221076-98-8
tert-butyl (1S)-1-(4-hydroxybenzyl)-2-oxo-2-(pentylamino)ethylcarbamate

: 221077-41-4
dimethyl (Z)-2-{4-[(2S)-2-[(4-methoxy-4-oxobutanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy}-2-butenedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / HCl / dioxane / 1.5 h / 20 °C

2: EDC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: 79 percent / Et₃N / tetrahydrofuran / 50 °C

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm010393s