5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

Base Information

Chemical Name:5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid
CAS No.:1445985-73-8
Molecular Formula:C₂₈H₃₂F₃N₃O₃
Molecular Weight:515.576
Hs Code.:

Synonyms:5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

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Chemical Property of 5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

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Technology Process of 5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

There total 19 articles about 5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1445985-72-7
methyl 5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoate

: 1445985-73-8
5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; for 3h;

Reference yield:

: 1445984-88-2
t-butyl (1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)carbamate

: 1445985-73-8
5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h

4: rhodium contaminated with carbon; hydrogen / ethyl acetate / 48 h / 30 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1224640-11-2
1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione

: 1445985-73-8
5-(3-((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropylamino)methyl)-4-(trifluoromethyl)phenyl)pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: triphenylphosphine / N,N-dimethyl-formamide / 2 h / 135 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 - 50 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5: potassium carbonate; potassium iodide / N,N-dimethyl-formamide

6: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 2 h

7: rhodium contaminated with carbon; hydrogen / ethyl acetate / 48 h / 30 °C

8: lithium hydroxide monohydrate; water / tetrahydrofuran / 3 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; borane-THF; lithium hydroxide monohydrate; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;