Technology Process of 18-acetoxy-25-<(trimethylsilyl)oxy>vitamin D3 tert-butyldimethylsilyl ether
There total 6 articles about 18-acetoxy-25-<(trimethylsilyl)oxy>vitamin D3 tert-butyldimethylsilyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation
2: 1.) BF3*Et2O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h
3: 73 percent / K2CO3 / methanol / 1 h / Ambient temperature
4: 37 percent / RuCl3*H2O, NaIO4 / acetonitrile; CCl4 / 60 h / 45 °C / aq. phosphate buffer (pH 7)
5: 86 percent / tetrahydrofuran / 1.5 h
6: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C
With
pyridine; lead(IV) acetate; ruthenium trichloride; sodium periodate; n-butyllithium; boron trifluoride diethyl etherate; potassium carbonate;
In
tetrahydrofuran; methanol; tetrachloromethane; acetonitrile; benzene;
DOI:10.1021/jo00037a046
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / LiAlH4 / diethyl ether
2: 91 percent / Pb(OAc)4, pyridine / benzene / 2.5 h / Ambient temperature; Irradiation
3: 1.) BF3*Et2O / 1.) ether, -20 deg C, 0.5 h, 2.) r. t., 0.5 h
4: 73 percent / K2CO3 / methanol / 1 h / Ambient temperature
5: 37 percent / RuCl3*H2O, NaIO4 / acetonitrile; CCl4 / 60 h / 45 °C / aq. phosphate buffer (pH 7)
6: 86 percent / tetrahydrofuran / 1.5 h
7: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C
With
pyridine; lead(IV) acetate; ruthenium trichloride; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; potassium carbonate;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; acetonitrile; benzene;
DOI:10.1021/jo00037a046
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 37 percent / RuCl3*H2O, NaIO4 / acetonitrile; CCl4 / 60 h / 45 °C / aq. phosphate buffer (pH 7)
2: 86 percent / tetrahydrofuran / 1.5 h
3: 1.) n-BuLi / 1.) hexanes, THF, -78 deg C, 2.) THF, -78 deg C
With
ruthenium trichloride; sodium periodate; n-butyllithium;
In
tetrahydrofuran; tetrachloromethane; acetonitrile;
DOI:10.1021/jo00037a046
