4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine

Base Information

• Chemical Name: 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine
• CAS No.: 240136-66-7
• Molecular Formula: C₁₀H₆ClF₃N₂S
• Molecular Weight: 278.685
• Mol file: 240136-66-7.mol

Synonyms:4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine

Chemical Property of 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine

There total 2 articles about 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-chloro-3-(trifluoromethyl)phenyl)ethanone (129825-11-2) + thiourea (17356-08-0) → 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (240136-66-7)

Guidance literature:

1-(4-chloro-3-(trifluoromethyl)phenyl)ethanone; With phenyltrimethylammonium tribromide; In tetrahydrofuran; at 20 ℃; for 0.5h;

thiourea; In ethanol; at 80 ℃; for 3h;

DOI:10.1016/j.bmc.2020.115531

Reference yield:

→ 4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (240136-66-7)

Guidance literature:

Reference yield: 76.0%

4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazole-2-amine (240136-66-7) + 5-[4-(ethoxycarbonyl)piperidin-1-yl]pyrazine-2-carboxylic acid → ethyl 1-[5-({4-[4-chloro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}carbamoyl)pyrazin-2-yl]piperidine-4-carboxylate

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmc.2020.115531

upstream raw materials:

1-(4-chloro-3-(trifluoromethyl)phenyl)ethanone

thiourea