ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

Base Information

Chemical Name:ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate
CAS No.:660451-37-6
Molecular Formula:C₃₇H₅₀N₄O₇
Molecular Weight:662.827
Hs Code.:

ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

Synonyms:ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

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Chemical Property of ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

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Technology Process of ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

There total 12 articles about ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 660451-36-5
tert-butyl {[6-((2-[(tert-butoxycarbonyl)amino]ethyl)amino)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate

: 4755-77-5
Ethyl oxalyl chloride

: 660451-37-6
ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

Guidance literature:: tert-butyl {[6-((2-[(tert-butoxycarbonyl)amino]ethyl)amino)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-3-yl]methyl}carbamate; With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃;

Ethyl oxalyl chloride; In water; ethyl acetate; for 0.5h;

Reference yield:

: 304854-54-4
2-amino-5-bromo-N-methoxy-N-methyl-benzamide

: 660451-37-6
ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: methanesulfonic acid / toluene / 6 h / Reflux

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 1 h / 90 °C / Inert atmosphere

4: tetrahydrofuran / 1 h / 20 °C

5: ammonia; hydrogen / tetrahydrofuran; methanol; water / 6 h / 20 °C / 3750.38 Torr

6: tetrahydrofuran / 0.5 h / 20 °C

7: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 20 °C

With methanesulfonic acid; ammonia; hydrogen; palladium diacetate; sodium hydrogencarbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; toluene; 2: Friedlaender synthesis;
DOI:10.1016/j.bmc.2011.06.032

Reference yield:

: 660451-32-1
6-bromo-4-(4-methylphenyl)-2-(2-methylpropyl)quinoline-3-carbonitrile

: 660451-37-6
ethyl ({2-[(tert-butoxycarbonyl)amino]ethyl}[3-{[(tert-butoxycarbonyl)amino]methyl}-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]amino)(oxo)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 1 h / 90 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / 20 °C

3: ammonia; hydrogen / tetrahydrofuran; methanol; water / 6 h / 20 °C / 3750.38 Torr

4: tetrahydrofuran / 0.5 h / 20 °C

5: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 20 °C

With ammonia; hydrogen; palladium diacetate; sodium hydrogencarbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; methanol; water; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2011.06.032