4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

Base Information

Chemical Name:4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile
CAS No.:1374159-50-8
Molecular Formula:C₁₇H₁₁ClFN₅S
Molecular Weight:371.825
Hs Code.:

Synonyms:4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

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Chemical Property of 4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

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Technology Process of 4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

There total 1 articles about 4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374159-47-3
3-(3-fluoropyridin-2-yl)aniline

: 33097-13-1
4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile

: 1374159-50-8
4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

: 1374159-50-8
4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

: 100-51-6,185532-71-2
benzyl alcohol

: 4-(benzyloxy)-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

: 4-(benzyloxy)-6-(3-(3-benzyloxypyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

Guidance literature:: benzyl alcohol; With sodium hydride; In 1-Methylpyrrolidine; at 20 ℃; for 0.5h;

4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile; In 1-Methylpyrrolidine; at 75 ℃; for 2h;

With sodium hydride; In 1-Methylpyrrolidine; at 75 ℃; for 0.5h;

Reference yield:

: 1374159-50-8
4-chloro-6-(3-(3-fluoropyridin-2-yl)phenylamino)-2-(methylthio)pyrimidin-5-carbonitrile

: (R)-2-(1-amino-1-oxobutan-2-ylamino)-4-(benzyloxy)-6-(3-(3-benzyoxypyridin-2-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1-Methylpyrrolidine / 0.5 h / 20 °C

1.2: 2 h / 75 °C

1.3: 0.5 h / 75 °C

2.1: peracetic acid / acetonitrile / 1 h / 20 °C

2.2: 1 h / 60 °C

3.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 1 h / 90 °C

With peracetic acid; dihydrogen peroxide; sodium hydride; potassium carbonate; In 1-Methylpyrrolidine; dimethyl sulfoxide; acetonitrile;