33097-13-1

Usage

Uses

Used in Organic Synthesis:
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is used as a synthetic building block for the development of new organic compounds. Its chemical structure allows it to be a versatile component in the synthesis of various molecules, particularly those with potential applications in pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is used as a key intermediate in the synthesis of therapeutic agents. Its unique chemical properties enable the development of novel drug candidates with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is also utilized in the agrochemical industry as a starting material for the synthesis of new pesticides and other crop protection agents. Its chemical structure can be modified to create compounds with enhanced efficacy and selectivity, contributing to the development of more effective and environmentally friendly agrochemical products.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is employed as a crucial component in the synthesis of various high-value chemicals. Its unique properties make it suitable for the development of compounds with specific applications in industries such as materials science, electronics, and coatings.

InChI:InChI=1/C6H3Cl2N3S/c1-12-6-10-4(7)3(2-9)5(8)11-6/h1H3

Upstream product

• 33097-12-0 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde oxime 
• 1979-98-2 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) 
• 33097-11-9 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 

Downstream Products

• 171511-23-2 4-Chloro-6-(2-chloro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 171511-22-1 4-(4-Bromo-phenylamino)-6-chloro-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 482344-45-6 3-(6-chloro-5-cyano-2-(methylthio)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 
• 482344-46-7 3-(5-cyano-6-(methyl(neopentyl)amino)-2-(methylthio)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 
• 868272-24-6 3-(5-cyano-6-(methyl(neopentyl)amino)-2-(methylsulfonyl)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 
• 627060-62-2 3-amino-4-chloro-1-methyl-6-methylthiopyrazolo[3,4-d]pyrimidine 
• 368889-83-2 [6-(4-Bromo-phenylamino)-5-cyano-2-methylsulfanyl-pyrimidin-4-ylsulfanyl]-acetic acid ethyl ester 
• 200626-99-9 [6-(2-Chloro-phenylamino)-5-cyano-2-methylsulfanyl-pyrimidin-4-ylsulfanyl]-acetic acid ethyl ester 
• 171511-19-6 5-Amino-4-(4-bromo-phenylamino)-2-methylsulfanyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 171511-20-9 5-Amino-4-(2-chloro-phenylamino)-2-methylsulfanyl-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 478180-41-5 4-chloro-6-[4-(4-fluoro-phenyl)-piperidin-1-yl]-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 357935-93-4 4-Chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 911370-59-7 5-chloro-1-(2,6-difluorophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 911370-61-1 5-chloro-1-(2,6-difluorophenyl)-7-(methylsulfinyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 

Relevant academic research and scientific papers

Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Chemoselectivity of chlorine versus methylthio (-SCH3), methylsulfinyl (-SOCH3), or methylsulfonyl [-S(O)2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studi

NOVEL COMPOUNDS

Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH

Provided herein are compounds having TNFα and/or PDE4 and/or B-RAF inhibitory activity, and compositions thereof. In particular, provided herein are compounds of the formula (I) and pharmaceutically acceptable salts, solvates, hydrates, clathrates, stereoisomers, polymorphs and prodrugs thereof, wherein Ar, R1, R2, R3, R4, n and Z are as described herein. Further provided herein are methods for treating or preventing various diseases and disorders by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors. In particular, provided herein are methods for preventing or treating cancer, inflammatory disorders, cognition and memory disorders and autoimmune disorders, or one or more symptoms thereof by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors.

NOVEL COMPOUNDS

Novel substituted l,5,7-trisubstituted-354-dihydro-pyriinido[4,5-(flpyrimidin- 2-(2H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

PROCESS FOR PREPARING PYRIDO[2,3-D]PYRIMIDIN-7-ONE AND 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE DERIVATIVES

The present invention is directed to a novel method of preparing of 2,4,8- trisubstituted pyrido[2,3-d]pyrimidin-7-one pharmacophores of Formula (II) or (Ha) wherein GHs CH2 Or NH: G2 is CH or nitrogen; Rx is chloro, bromo, iodo, or O-S(O)

2,4,5,6-Tetrasubstituted pyrimidines and salts thereof

Compounds of the formula SPC1 Wherein R1 is alkoxy of 1 to 3 carbon atoms, morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, or EQU1 where A is hydrogen, alkanoyl of 1 to 4 carbon atoms, alkenoyl of 2 to 4 carbon atoms, methoxy-(alkanoyl of 1 to 4 carbon atoms), carboxyl-(alkanoyl of 1 to 4 carbon atoms), acetyl-(alkanoyl of 1 to 4 carbon atoms), methoxy-(alkenoyl of 2 to 4 carbon atoms), carboxyl-(alkenoyl of 2 to 4 carbon atoms), acetyl-(alkenoyl of 2 to 4 carbon atoms), aminocarbonyl, mono(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, di-(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, methoxymethylaminocarbonyl, pyridinoyl, salicyloyl, furanoyl, or (alkyl of 1 to 3 carbon atoms)-sulfonyl, R2 is morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, piperazino or N'-[acetyl-(alkanoyl of 1 to 3 arbon atoms)]-piperazino, R3 is hydrogen, chlorine, bromine, nitro, cyano, formyl, acetyl or carbalkoxy of 2 to 4 carbon atoms, and R4 is hydrogen, chlorine, bromine, cyano, carbalkoxy of 2 to 4 carbon atoms, alkyl of 1 to 6 carbon atoms, mono(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, di(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, hydroxyl, allyloxy, alkoxy of 1 to 6 carbon atoms, mercapto, allylmercapto, (alkyl of 1 to 6 carbon atoms)-mercapto, 1-oxidothiomorpholino, or where B is hydrogen, alkyl of 1 to 3 carbon atoms, cyclohexyl, phenyl, chloro-phenyl, carboxy-phenyl, carbomethoxy-phenyl or pyridyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.