33097-13-1

Basic information

• Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
• Synonyms: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBONITRILE;5-Cyano-4,6-dichloro-2-(methylthio)pyrimidine;,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE;5-PyriMidinecarbonitrile, 4,6-dichloro-2-(Methylthio)-;4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbonitrile
• CAS NO: 33097-13-1
• Molecular Formula: C₆H₃Cl₂N₃S
• Molecular Weight: 220.08
• Product Categories: Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;Sulfur & Selenium Compounds;Heterocycle-Pyrimidine series
• Mol File: 33097-13-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 103-105°C
• Boiling Point: 367.3 °C at 760 mmHg
• Flash Point: 175.9 °C
• Appearance: /
• Density: 1.58 g/cm³
• Vapor Pressure: 1.38E-05mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Ethyl Acetate
• PKA: -7.56±0.39(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(33097-13-1)
• EPA Substance Registry System: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE(33097-13-1)

Safety Data

• Hazard Codes: T,C
• Statements: 25-34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2923
• WGK Germany: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 33097-13-1(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.

InChI:InChI=1/C6H3Cl2N3S/c1-12-6-10-4(7)3(2-9)5(8)11-6/h1H3

Upstream product

• 33097-11-9 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 
• 1979-98-2 2,4-dihydroxy-2-methylmercaptopyrimidine (zwitterionic form) 
• 33097-12-0 4,6-dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde oxime 

Downstream Products

• 171511-23-2 4-Chloro-6-(2-chloro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbonitrile 
• 482344-45-6 3-(6-chloro-5-cyano-2-(methylthio)pyrimidin-4-ylamino)-N-methoxy-4-methylbenzamide 
• 56035-75-7 4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carbonitrile 
• 911370-59-7 5-chloro-1-(2,6-difluorophenyl)-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 911370-61-1 5-chloro-1-(2,6-difluorophenyl)-7-(methylsulfinyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 911370-69-9 4-(8-(2,6-difluorophenyl)-2-{[2-(dimethylamino)ethyl]amino}-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)-3-methylbenzoic acid 
• 960308-87-6 3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methylbenzoic acid 
• 911693-61-3 3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide 
• 911693-73-7 3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-N,4-dimethylbenzamide 
• 911693-62-4 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide 
• 911693-57-7 3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-propylbenzamide 
• 911693-58-8 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-propylbenzamide 
• 911693-43-1 N-{3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methylphenyl}-3-thiophenecarboxamide 

Relevant articles and documents

Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Chemoselectivity of chlorine versus methylthio (-SCH3), methylsulfinyl (-SOCH3), or methylsulfonyl [-S(O)2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studi

NOVEL COMPOUNDS

Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.

NOVEL COMPOUNDS

Novel substituted l,5,7-trisubstituted-354-dihydro-pyriinido[4,5-(flpyrimidin- 2-(2H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.