ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

Base Information

Chemical Name:ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate
CAS No.:170366-65-1
Molecular Formula:C₃₁H₃₇F₃N₂O₄
Molecular Weight:558.641
Hs Code.:

Synonyms:ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

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Chemical Property of ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

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Technology Process of ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

There total 6 articles about ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 112290-16-1
4-(2-aminophenoxy)-butanoic acid ethyl ester

: 170366-80-0
(Z)-4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-2-butenoic acid

: 170366-65-1
ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

Guidance literature:: With tributyl-amine; 2-chloromethylpyridinium iodide; In dichloromethane; for 0.5h; Heating;

Reference yield:

: 170366-89-9
2,2,2-trifluoro-1-[1-(1-propylbutyl)indol-5-yl]-1-ethanone

: 170366-65-1
ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: 29 percent / NaH / tetrahydrofuran / 0.25 h / -30 °C

2: 100 percent / aq. LiOH / dioxane / 3 h / 20 °C

3: 79 percent / 2-chloromethylpyridinium iodide; tributylamine / CH₂Cl₂ / 0.5 h / Heating

With lithium hydroxide; tributyl-amine; 2-chloromethylpyridinium iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Wittig reaction;

Reference yield:

: 170366-79-7
methyl (Z)-4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-2-butenoate

: 170366-65-1
ethyl (Z)-4-{2-[[4,4,4-trifluoro-3-[1-(1-propyl)butylindol-5-yl]-1-oxo-2-butenyl]amino]phenoxy}butyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. LiOH / dioxane / 3 h / 20 °C

2: 79 percent / 2-chloromethylpyridinium iodide; tributylamine / CH₂Cl₂ / 0.5 h / Heating

With lithium hydroxide; tributyl-amine; 2-chloromethylpyridinium iodide; In 1,4-dioxane; dichloromethane;