16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate

Base Information

• Chemical Name: 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate
• CAS No.: 62201-86-9
• Molecular Formula: C₂₉H₄₀O₆S
• Molecular Weight: 516.699
• Mol file: 62201-86-9.mol

Synonyms:16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate

Chemical Property of 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate

There total 3 articles about 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-hydroxy-16-(hydroxymethylene)androst-5-en-17-one (2405-43-8) → 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate (62201-86-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine

2: potassium borohydride; acetic acid / methanol; ethanol / pH 6 - 8

3: pyridine

With pyridine; potassium borohydride; acetic acid; In methanol; ethanol;

DOI:10.3390/molecules16064786

Reference yield:

3β-acetoxy-16-acetoxymethylene-5-androsten-17-one (21934-29-2) → 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate (62201-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium borohydride; acetic acid / methanol; ethanol / pH 6 - 8

2: pyridine

With pyridine; potassium borohydride; acetic acid; In methanol; ethanol;

DOI:10.3390/molecules16064786

Reference yield:

16β-hydroxymethylandrost-5-ene-3β,17β-diol 3-acetate (37492-77-6) + p-toluenesulfonyl chloride (98-59-9) → 16β-p-toluenesulfonyloxymethylandrost-5-ene-3β,17β-diol 3-acetate (62201-86-9)

Guidance literature:

With pyridine;

upstream raw materials:

16β-hydroxymethylandrost-5-ene-3β,17β-diol 3-acetate

p-toluenesulfonyl chloride

3β-hydroxy-16-(hydroxymethylene)androst-5-en-17-one

3β-acetoxy-16-acetoxymethylene-5-androsten-17-one

Downstream raw materials:

3β-acetoxy-16β-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)androst-5-en-17β-ol

3β-acetoxy-16β-[4-(4-ethylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol

3β-acetoxy-16β-[4-(3-tolyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol

3β-acetoxy-16β-[4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-ylmethyl]androst-5-en-17β-ol