2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

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Chemical Name:2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole
CAS No.:925216-72-4
Molecular Formula:C₂₃H₂₈N₄O₃
Molecular Weight:408.5
Hs Code.:

Synonyms:2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

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Chemical Property of 2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

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Technology Process of 2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

There total 6 articles about 2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.3%

: 925216-71-3
2-(4-ethoxyphenyl)-N-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)-5-nitrophenyl)acetamide

: 925216-72-4
2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

Guidance literature:: 2-(4-ethoxyphenyl)-N-(2-(2-(1-methylpyrrolidin-2-yl)ethylamino)-5-nitrophenyl)acetamide; With phosphorus pentachloride; In chloroform; for 4.5h; Heating / reflux;

With ammonia; In chloroform; water; pH=9 - 10;

Reference yield:

: 925216-69-9
N-(2-(1-methylpyrrolidin-2-yl)ethyl)-2,4-dinitroaniline

: 925216-72-4
2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium sulfide / ethanol; water / 2.5 h / 65 - 70 °C / Inert atmosphere

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

3: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

With ammonium sulfide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In ethanol; dichloromethane; chloroform; water; 1: Zinin reduction;
DOI:10.1021/ml200268w

Reference yield:

: 4919-33-9
4-ethoxyphenylacetic acid

: 925216-72-4
2-(4-ethoxybenzyl)-1-(2-(1-methylpyrrolidin-2-yl)ethyl)-5-nitro-1H-benzo[d]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 18 h / 35 °C / Inert atmosphere

2: phosphorus trichloride / chloroform / 4 h / Reflux; Inert atmosphere

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; phosphorus trichloride; In dichloromethane; chloroform;
DOI:10.1021/ml200268w