4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester
• CAS No.: 1263903-03-2
• Molecular Formula: C₂₁H₁₉N₃O₂S
• Molecular Weight: 377.467
• Mol file: 1263903-03-2.mol

Synonyms:4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester

Chemical Property of 4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester

There total 1 articles about 4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-benzyl-1H-benzoimidazole-2-carbothioic acid amide (1263902-95-9) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester (1263903-03-2)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1016/j.ejmech.2010.11.014

Reference yield: 72.0%

4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester (1263903-03-2) → 2-(1-benzyl-1H-benzoimidazol-2-yl)-4-methyl-thiazole-5-carboxylic acid (1263903-13-4)

Guidance literature:

4-methyl-2-(1-benzyl-1H-benzoimidazol-2-yl)-thiazole-5-carboxylic acid ethyl ester; With water; potassium hydroxide; In methanol; for 2.5h; Reflux;

With hydrogenchloride; In methanol; water; pH=3 - 4;

DOI:10.1016/j.ejmech.2010.11.014

upstream raw materials:

1-benzyl-1H-benzoimidazole-2-carbothioic acid amide

ethyl 2-chloro-3-oxo-butyrate

Downstream raw materials:

2-(1-benzyl-1H-benzoimidazol-2-yl)-4-methyl-thiazole-5-carboxylic acid