Z(OMe)-Asp(OBzl)-Gly-OBzl

Base Information

• Chemical Name: Z(OMe)-Asp(OBzl)-Gly-OBzl
• CAS No.: 101301-48-8
• Molecular Formula: C₂₉H₃₀N₂O₈
• Molecular Weight: 534.566
• Mol file: 101301-48-8.mol

Synonyms:Z(OMe)-Asp(OBzl)-Gly-OBzl

Chemical Property of Z(OMe)-Asp(OBzl)-Gly-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z(OMe)-Asp(OBzl)-Gly-OBzl

There total 1 articles about Z(OMe)-Asp(OBzl)-Gly-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Gly-OBz (1738-68-7) + Z(OMe)-Asp(OBzl)-ONp (53049-30-2) → Z(OMe)-Asp(OBzl)-Gly-OBzl (101301-48-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1248/cpb.33.3205

Reference yield:

Z(OMe)-Asp(OBzl)-Gly-OBzl (101301-48-8) → Z-Ala-Ser-Asp(OBzl)-Gly-OBzl (101301-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA/anisole / 1 h

2: Et₃N / dimethylformamide / 4 °C

With methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.3205

Reference yield:

Z(OMe)-Asp(OBzl)-Gly-OBzl (101301-48-8) → Z(OMe)-His-Ala-Asp(OBzl)-Gly-OBzl (101301-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA/anisole / 1 h

2: Et₃N / dimethylformamide / 4 °C

With methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.3205

upstream raw materials:

Gly-OBz

Z(OMe)-Asp(OBzl)-ONp

Downstream raw materials:

L-aspartylglycine dibenzylester

Z-Ala-Ser-Asp(OBzl)-Gly-OBzl

Z(OMe)-His-Ala-Asp(OBzl)-Gly-OBzl

Z-Lys(Z)-Ser-Asp(OBzl)-Gly-OBzl

Refernces