tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate
CAS No.:917610-12-9
Molecular Formula:C₂₇H₃₇N₃O₃
Molecular Weight:451.609
Hs Code.:

Synonyms:tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

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Technology Process of tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

There total 6 articles about tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 40320-60-3
N-benzhydryl 3-azetidinone

: 917610-11-8
tert-butyl {2-[(3R)-morpholin-3-yl]ethyl}carbamate

: 917610-12-9
tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

Guidance literature:: N-benzhydryl 3-azetidinone; tert-butyl {2-[(3R)-morpholin-3-yl]ethyl}carbamate; With polymer-bound trimethyl ammonium cyanoborohydride; acetic acid; In methanol; at 120 ℃; for 0.133333h; Polystyrene Microwave irradiation;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 917572-28-2
(S)-4-benzyl-3-(chloromethyl)morpholine

: 917610-12-9
tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / Heating / reflux

2: potassium hydroxide; isopropyl alcohol / Raney nickel / 6 h / Heating / reflux

3: triethylamine / tetrahydrofuran / 1 h / 20 °C

4: hydrogen / palladium(II) hydroxide/carbon; acetic acid / ethanol / 20 °C / 3750.38 Torr

5: polymer-bound trimethyl ammonium cyanoborohydride; acetic acid / methanol / 0.13 h / 120 °C / Microwave irradiation

With potassium hydroxide; sodium hydroxide; polymer-bound trimethyl ammonium cyanoborohydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; isopropyl alcohol; palladium(II) hydroxide/carbon; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 917610-09-4
{2-[(3R)-4-benzylmorpholin-3-yl]ethyl}amine

: 917610-12-9
tert-butyl (2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2: hydrogen / palladium(II) hydroxide/carbon; acetic acid / ethanol / 20 °C / 3750.38 Torr

3: polymer-bound trimethyl ammonium cyanoborohydride; acetic acid / methanol / 0.13 h / 120 °C / Microwave irradiation

With polymer-bound trimethyl ammonium cyanoborohydride; hydrogen; acetic acid; triethylamine; palladium(II) hydroxide/carbon; acetic acid; In tetrahydrofuran; methanol; ethanol;