917572-28-2 Usage
Description
(S)-4-Benzyl-3-chloromethyl-morpholine, a chiral molecule belonging to the morpholine family, is characterized by its unique chemical properties due to the presence of a morpholine ring with a benzyl group and a chloromethyl group attached to it. (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE serves as a versatile building block in the synthesis of pharmaceuticals and agrochemicals, and exhibits potential antifungal and antibacterial properties, positioning it as a valuable asset in the development of new drugs and agricultural products.
Uses
Used in Pharmaceutical Industry:
(S)-4-Benzyl-3-chloromethyl-morpholine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its unique reactivity and structural features, contributing to the development of innovative medications.
Used in Agrochemical Industry:
In the agrochemical sector, (S)-4-Benzyl-3-chloromethyl-morpholine is utilized as a precursor in the creation of novel agrochemicals, leveraging its potential antifungal and antibacterial properties to enhance crop protection and yield.
Used in Drug Development:
(S)-4-Benzyl-3-chloromethyl-morpholine is employed as a promising candidate in drug development, particularly for its potential applications in treating fungal and bacterial infections, due to its inherent bioactivity against these microorganisms.
Used in Chemical Research:
(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE is also used as a subject of chemical research to explore its reactivity, synthesis pathways, and potential applications in various chemical processes, further expanding its utility in the scientific community.
Check Digit Verification of cas no
The CAS Registry Mumber 917572-28-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,7,5,7 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 917572-28:
(8*9)+(7*1)+(6*7)+(5*5)+(4*7)+(3*2)+(2*2)+(1*8)=192
192 % 10 = 2
So 917572-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H16ClNO/c13-8-12-10-15-7-6-14(12)9-11-4-2-1-3-5-11/h1-5,12H,6-10H2/t12-/m1/s1
917572-28-2Relevant articles and documents
Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors
Liu, Yifu,Xie, Zuoquan,Zhao, Dan,Zhu, Jin,Mao, Fei,Tang, Shuai,Xu, Hui,Luo, Cheng,Geng, Meiyu,Huang, Min,Li, Jian
, p. 2227 - 2244 (2017/04/03)
Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described bis(4-morpholinyl thiocarbonyl)-disulfide (JX06, 16) as the first covalent inhibitor of PDK1. Here, on the basis of the scaffold of 16, we identify two novel types of disulfide-based PDK1 inhibitors. The most potent analogue, 3a, effectively inhibits PDK1 both at the molecular (kinact/Ki = 4.17 × 103 M-1 s-1) and the cellular level (down to 0.1 μM). In contrast to 16, 3a is a potent and subtype-selective inhibitor of PDK1 with >40-fold selectivity for PDK2-4. 3a also significantly alters glucose metabolic pathways in A549 cells by decreasing ECAR and increasing ROS. Moreover, in the xenograft models, 3a shows significant antitumor activity with no negative effect to the mice weight. Collectively, these data demonstrate that 3a may be an excellent lead compound for the treatment of cancer as a first-generation subtype-selective and covalent PDK1 inhibitor.
NEW AZETIDINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES
-
Page/Page column 32, (2008/06/13)
The application relates to new piperazine- or morpholine-substituted azetidine derivatives of formula I. These compounds are antagonists at the neurokinin receptor and can be used for the treatment of gastrointestinal diseases. The application also relate
