1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

Base Information

Chemical Name:1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine
CAS No.:125348-94-9
Molecular Formula:C₂₁H₂₈Cl₂N₂O₃
Molecular Weight:427.371
Hs Code.:

Synonyms:1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

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Chemical Property of 1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

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Technology Process of 1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

There total 4 articles about 1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 125348-92-7
1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde

: 177-11-7
4,4-ethylenedioxy-piperidine

: 125348-94-9
1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

Guidance literature:: With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 72h; Ambient temperature;
DOI:10.1021/jm00081a009

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 125348-94-9
1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 20 min, 2.) acetonitrile, RT, 6 h

2: 69 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 66 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH₃CN / methanol / 72 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;
DOI:10.1021/jm00081a009

Reference yield:

: 128103-38-8
1-<(3,4-dichlorophenyl)acetyl>-2-piperidinemethanol

: 125348-94-9
1-<(3,4-dichlorophenyl)acetyl>-2-<(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)methyl>piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 66 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH₃CN / methanol / 72 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; dichloromethane;
DOI:10.1021/jm00081a009